ExMI Clinical Bibliography Pelvic Wave and REACT

Overview: In 2017, React Innovations acquired the assets of Magic Race/Neotonus which manufactured and distributed the Extracorporeal Magnetic Innervation (ExMI) therapy. The non-invasive technology can stimulate muscles, nerves and tendons up to 4 inches deep into the body. Patients are treated with their clothes on as the bio-electric magnetic therapy requires no skin contact in order to actuate the tissues. Videos of the technology in action can be found online at our websites. The company manufactures tables, chairs and hand-held units utilizing its core technology. All products are manufactured in the USA utilizing ISO-13485 manufacturing standards. Pelvic Wave, LLC is a subsidiary of React Holdings, LLC focused on the Pelvic Floor / Incontinence therapy market. ExMI therapy has two issued 510(k) issuances from the FDA. The device is classified as a Class II – Power Muscle Stimulator.

ExMI Mechanism: Pulses of steep gradient magnetic flux are produced by the therapy head (magnet). These fields penetrate the patient’s perineum and initiate nerve impulses that ultimate innervate both the smooth and striated muscles, causing them to contract. The time-varying magnetic fields create an electrical potential that causes ion flow (Eddy currents) within the targeted tissues. This ion flow results in the results ion resting motor neuron membrane potentials greater than the threshold potential necessary to start an action potential. Once this action potential has been realized, the sodium (Na+) and potassium (K+) ions flow across the neuron membrane. This action propagates a nerve impulse to the motor end plate. The musculature responds with contractions as a rate determined by the output pulse rate of the system. If the output pulse rate exceeds that of the muscles ability to contract and relax with each pulse, the result is a constant and steady contraction of the muscles.

Studies: The following references a total of 67 studies performed over 20+ years citing the Extracorporeal Magnetic Innervation (ExMI) therapy.

• 45 on pelvic floor and incontinence
• 13 on traditional rehabilitation
• 10 on animal and physiological studies